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ea0090oc7.2 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2023

BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

Martinez-Barbera Juan Pedro , Manshaei Saba , Willis Thea , Reen Virinder , Pallikonda Hussayn , Withers Dominic , Gil Jesus , Andoniadou Cynthia

Introduction: Hormone-producing pituitary cell lineages derive from SOX2+ embryonic precursors. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing extensively to all the endocrine cell lineages. Additionally, paracrine signalling from PSCs is important for cell proliferation of neighbouring progenitors (PMC7803373). It is not known if SOX2+ PSCs are involved in the regulation of additio...

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ea0086oc3.2 | Reproductive and Neuroendocrinology | SFEBES2022

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

Willis Thea L , Manshaei Saba , Reen Virinder , Pallikonda Husayn , Birch Jodie , Yianni Val , Lodge Emily J , Withers Dominic , Gil Jesus , Martinez-Barbera Juan Pedro , Andoniadou Cynthia L

The pituitary gland is a critical endocrine organ regulating multiple essential physiological processes including growth, reproduction, metabolism and the stress response. Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing the transcription factor SOX2. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing to all the endocrine cell li...

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Endocrine Abstracts

BRF1-Mediated Paracrine Signalling by a Subset of SOX2-Expressing Stem Cells is required for Normal Development of the Stem Cell Compartment and Terminal Differentiation of Pituitary Committed Progenitors

BRF1-mediated paracrine signalling from pituitary stem cells is required for terminal differentiation of pituitary committed progenitors

BiosciAbstracts